Pr Galli will present the role of oxidative metabolism in alcoholic liver disease, during the Targeting Liver Diseases World Congress 2015
The role of oxidative metabolism in the pathogenesis of alcoholic liver disease will be the focus of Pr Galli during the Targeting Liver Diseases World Congress 2015, held in Malta between the 25-26th June 2015.
"Although the pathogenesis of alcoholic liver disease (ALD) involves complex and still unclear biological processes, the oxidative metabolites of ethanol such as acetaldehyde (AcCHO) and reactive oxygen species (ROS) play a preeminent role in the clinical and pathological spectrum of ALD.
Furthermore, activation of innate and adaptive immunity in response of ethanol metabolism plays a key role in the development and progression of ALD. Ethanol metabolism may also interfere with cell mediated adaptive immunity by impairing proteosome function in macrophage and dendritic cells and consequently alters allogenic antigen presentation.Finally, AcCHO and ROS have a role in alcohol-related carcinogenesis because they can bind DNA and form adducts that are prone to mutagenesis, interfere with DNA methylation, synthesis and repair, thereby increasing hepatocellular carcinoma susceptibility."
To know more about the preliminary agenda of Targeting Liver World Congress 2015, please click here
